The mission of the Neuromodulation facility is to provide noninvasive magnetic (TMS) and electric (tDCS/tACS/tRNS, PNS, PAS) brain stimulation capabilities with the whole spectrum of applications, from virtual lesion approaches, over single and paired pulse mono-focal applications to determine intracortical interactions (e.g., gaba-ergic, gluatamate-ergic), bifocal applications to determine interregional interactions (e.g., interhemispherical) towards neuromodulation including modulation of oscillatory activity. This all can be done neuronavigated if excellent individual focality of the application is important.
In August 2016, the Facility room was arranged/furnished and core of the TMS equipment was delivered and installed. The neuromodulation facility was open officially on October 2016 and the equipment training and the first experiment began on January 2017.
The TMS equipment includes:
- a single and paired-pulse stimulator set-up (Magstim BiStim2),
- a high-power repetitive pulse stimulator (rTMS; Magstim Super Rapid2 Plus1),
- an MRI-image guided neuronavigation system for placement of stimulating coils (Brainsight TMS),
- a high-quality wireless EMG acquisition system (Noraxon DTS),
- two TMS-specific experimental chairs with coil montage arms.
The transcranial electric stimulation equipment will include:
- MR-compatible tES Stimulation systems (Neuroconn)
- Mobile/Home-based, remotely controlled systems (Neuroelectrics)
The facility is dedicated to perform scientific projects using brain stimulation techniques in healthy subjects and also in patients with neuropsychiatric diseases. The close vicinity to the Clinical and Sleep Research Unit (CSRU) warrants adequate patient management. The CSRU is equipped to monitor clinically ambulatory patients, contains an automatized hospital bed, a tensiometer, a resuscitation trolley, a wheelchair and a nurse/TSM technician is present on site for medical assistance if needed.
Its vicinity to the other platforms, particularly EEG and MRI, is a considerable benefit and warrants to perform multi-modal research protocols in combination with non-invasive brain stimulation.
Scientific leadership of this facility is managed by Pr. Friedhelm Hummel (EPFL) and Pr. Anne-Lise. Giraud (UNIGE).
The manager of the neuromodulation facility will be hired in 2017.