Lieu / Hôte

Campus Biotech,
Room B1.06

Neuro-X Seminar: Towards thalamic visual prosthetics

The lateral geniculate nucleus (LGN), a retinotopic relay center where visual inputs from the retina are processed and relayed to the visual cortex, has been proposed as a potential target for artificial vision.  At present, it is unknown whether optogenetic LGN stimulation is sufficient to elicit behaviourally relevant percepts and the properties of LGN neural responses relevant for artificial vision have not been thoroughly characterized.  We demonstrate that tree shrews pretrained on a visual detection task can detect optogenetic LGN activation using an AAV2-CamKIIα-ChR2 construct and readily generalize from visual to optogenetic detection.  As temporal aspects of artificial stimulation are crucial, we also examined tree shrew discrimination performance for visual flicker.  Neural decoding analyses in LGN and primary visual cortex (V1) reveal that while LGN neurons multiplex information about temporal stimulation discriminations, V1 neurons explicitly encode information about one or the other discriminations but not both.  Our findings confirm the LGN as a potential target for visual prosthetics and introduce a distinction in stimulus encoding between thalamic and cortical representations that could be of fundamental importance in artificial vision.

Participate in the seminar given by the EPFL Neuro-X Institute on February 15, 2023 16:00 - 17:00 in Campus Biotech.

  • Speaker: Prof Gregor Rainer, University of Fribourg
  • Location: Campus Biotech, room B1.06 or online

Free participation, More information here.